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Company ReportsAgios Pharmaceuticals

Agios Pharmaceuticals(AGIO)

Agios Pharmaceuticals Inc. is a public American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.: Table 1

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Pyrukynd	Mitapivat	2022-02-17	2031-2041	Inborn genetic diseases , Hemolytic anemia

Clinical Trials

Therapeutic Areas:

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Classification:

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All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

,

hepatic insufficiency

,

,

kidney diseases

,

,

hemolytic anemia congenital nonspherocytic

,

sickle cell anemia

,

,

beta-thalassemia

,

alpha-thalassemia

,

inborn errors pyruvate metabolism

,

hemolytic anemia

,

renal insufficiency

,

,

t-cell lymphoma

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

t-cell lymphoma peripheral

,

intestinal diseases

,

,

neuroendocrine tumors

,

carcinoid tumor

,

malignant carcinoid syndrome

,

carcinoid heart disease

,

serotonin syndrome

,

,

colorectal neoplasms

,

muscular atrophy

,

multiple sclerosis

,

substance-related disorders

,

,

healthy volunteers/patients

,

,

small cell lung carcinoma

,

alzheimer disease

,

prostatic hyperplasia

,

,

sleep wake disorders

,

premature ejaculation

,

embryo transfer

,

,

atopic dermatitis

,

,

,

bacillary dysentery

,

,

,

atherosclerosis

,

,

relapsing-remitting multiple sclerosis

,

,

,

,

ulcerative colitis

,

,

,

ovarian neoplasms

,

prostatic neoplasms

,

multiple myeloma

,

plasma cell neoplasms

,

disease progression

,

,

,

type 1 diabetes mellitus

,

chronic renal insufficiency

,

kidney diseases

,

,

,

,

biliary liver cirrhosis

,

,

intrahepatic cholestasis

,

,

chronic hepatitis b

,

chronic hepatitis

,

erectile dysfunction

,

lower urinary tract symptoms

,

,

,

pulmonary emphysema

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

non-hodgkin lymphoma

,

uterine cervical neoplasms

,

essential thrombocythemia

,

polycythemia vera

,

primary myelofibrosis

,

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

myeloid leukemia acute

,

myeloid leukemia

,

salmonella infections

,

breast neoplasms

,

human influenza

,

streptococcal infections

,

,

,

haemophilus influenzae type b

,

diabetes mellitus

,

,

,

,

,

,

,

pneumococcal pneumonia

,

,

,

large b-cell lymphoma diffuse

,

,

meningococcal meningitis

,

parkinson disease

,

,

,

,

depressive disorder

,

,

neisseria meningitidis

,

restless legs syndrome

,

psychomotor agitation

,

,

streptococcus pneumoniae

,

communicable diseases

,

systemic lupus erythematosus

,

,

major depressive disorder

,

,

,

meningococcal infections

,

post-traumatic stress disorders

,

traumatic stress disorders

,

,

rotavirus infections

,

mucinous adenocarcinoma

,

ductal carcinoma breast

,

inflammatory breast neoplasms

,

,

respiratory syncytial virus infections

,

bipolar disorder

,

,

,

,

,

chronic obstructive pulmonary disease

,

,

,

type 2 diabetes mellitus

,

acquired immunodeficiency syndrome

,

,

,

,

,

,

obstructive lung diseases

,

,

irritable bowel syndrome

,

immunologic deficiency syndromes

,

,

,

,

post-traumatic headache

,

cognitive dysfunction

,

,

myofascial pain syndromes

,

,

respiratory tract diseases

,

respiration disorders

,

bronchial spasm

,

,

,

bacterial infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

autoimmune diseases

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

papillomavirus infections

,

,

exercise-induced asthma

,

endometrial neoplasms

,

stomach neoplasms

,

head and neck neoplasms

,

,

,

,

non-alcoholic fatty liver disease

,

,

financial stress

prostatic hyperplasia

,

,

healthy volunteers/patients

,

respiratory tract diseases

,

respiration disorders

,

,

kidney diseases

,

,

,

,

,

respiratory tract infections

,

,

premature obstetric labor

,

,

pulmonary edema

,

,

bacterial infections

,

,

hepatic insufficiency

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

breast neoplasms

,

,

,

atherosclerosis

,

obstructive lung diseases

,

,

pancreatic neoplasms

,

,

follicular lymphoma

,

allergic rhinitis

,

pulmonary tuberculosis

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

sjogren's syndrome

,

,

,

,

,

,

systemic lupus erythematosus

,

,

acquired immunodeficiency syndrome

,

,

type 2 diabetes mellitus

,

human influenza

,

communicable diseases

,

,

neoplasm metastasis

,

,

parkinson disease

,

,

migraine disorders

,

,

major depressive disorder

,

depressive disorder

,

churg-strauss syndrome

,

granulomatosis with polyangiitis

,

systemic vasculitis

,

eosinophilic granuloma

,

neisseria meningitidis

,

haemophilus influenzae type b

,

restless legs syndrome

,

psychomotor agitation

,

,

,

,

,

ovarian neoplasms

,

,

,

chronic obstructive pulmonary disease

,

,

diabetes mellitus

,

,

,

,

pulmonary eosinophilia

,

prostatic neoplasms

,

growth and development

,

,

,

postherpetic neuralgia

,

renal cell carcinoma

,

human influenza

,

nutritional status

,

pneumococcal infections

,

pneumococcal pneumonia

,

,

,

systemic lupus erythematosus

,

cutaneous lupus erythematosus

,

inflammatory bowel diseases

,

,

,

tendon injuries

,

,

haemophilus influenzae

,

streptococcus pneumoniae

,

,

,

,

energy metabolism

,

endometrial neoplasms

,

,

mullerian mixed tumor

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

non-small-cell lung carcinoma

,

,

neoplasm metastasis

,

,

falciparum malaria

,

ovarian neoplasms

,

brain neoplasms

,

healthy volunteers/patients

,

prostatic neoplasms

,

,

,

colorectal neoplasms

,

squamous cell carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

ovarian epithelial carcinoma

,

cutaneous malignant melanoma

,

,

type 1 diabetes mellitus

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

sickle cell anemia

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

chronic hepatitis b

,

,

primary myelofibrosis

,

hepatocellular carcinoma

,

liver neoplasms

,

fallopian tube neoplasms

,

pancreatic neoplasms

,

,

hematologic neoplasms

,

ductal carcinoma

,

circulating neoplastic cells

,

uterine neoplasms

,

uterine cervical neoplasms

,

,

streptococcus agalactiae

,

,

follicular lymphoma

,

neisseria meningitidis

,

haemophilus influenzae type b

,

invasive hydatidiform mole

,

biliary tract neoplasms

,

uveal neoplasms

,

respiratory tract diseases

,

respiration disorders

,

,

focal segmental glomerulosclerosis

,

cytomegalovirus infections

,

chronic hepatitis

,

kidney diseases

,

membranous glomerulonephritis

,

nephrotic syndrome

,

,

,

endometrioid carcinoma

,

breast diseases

,

squamous cell neoplasms

,

neurofibromatosis 2

,

acoustic neuroma

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

pulmonary tuberculosis

,

adenocarcinoma of lung

,

disease progression

,

peritoneal neoplasms

,

,

beta-thalassemia

,

,

sickle cell trait

,

essential thrombocythemia

,

polycythemia vera

,

,

,

,

,

breast neoplasms

,

,

rheumatoid arthritis

,

,

head and neck neoplasms

,

inflammatory breast neoplasms

,

,

respiratory syncytial virus infections

,

,

bacterial infections

,

,

streptococcal infections

,

,

stomach neoplasms

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

infectious skin diseases

,

bacterial skin diseases

,

ductal carcinoma breast

,

renal insufficiency

,

,

,

,

urinary bladder neoplasms

,

acute coronary syndrome

,

,

rotavirus infections

,

,

mucinous adenocarcinoma

,

,

meningococcal meningitis

,

,

respiratory syncytial viruses

,

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

acquired immunodeficiency syndrome

,

,

chronic obstructive pulmonary disease

,

,

communicable diseases

,

obstructive lung diseases

,

,

dental focal infection

,

focal infection

,

,

,

immunologic deficiency syndromes

,

ventilator-associated pneumonia

,

growth and development

,

immunologic tests

,

,

alzheimer disease

,

wasting syndrome

,

,

,

insulin resistance

,

abdominal obesity

,

lipid metabolism

,

latent autoimmune diabetes in adults

,

community-acquired infections

,

,

,

staphylococcal infections

,

resistance training

,

,

,

major depressive disorder

,

depressive disorder

,

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

brain neoplasms

,

,

wounds and injuries

,

traumatic brain injuries

,

,

,

ovarian epithelial carcinoma

,

neoplasm metastasis

,

cystic fibrosis

,

pancreatic cyst

,

,

,

thyroid neoplasms

,

thyroid diseases

,

central nervous system neoplasms

,

nervous system neoplasms

,

,

thoracic neoplasms

,

unilateral breast neoplasms

,

,

,

,

squamous cell carcinoma

,

squamous cell neoplasms

,

,

,

,

subarachnoid hemorrhage

,

prostatic neoplasms

,

,

,

,

,

,

healthy volunteers/patients

,

,

,

,

breast neoplasms

,

uterine cervical neoplasms

,

,

ovarian neoplasms

,

,

,

lactic acidosis

,

kidney neoplasms

,

,

pancreatic ductal carcinoma

,

,

cardiovascular diseases

,

myelodysplastic syndromes

,

,

,

neuroendocrine tumors

,

neuroendocrine carcinoma

,

thiamine deficiency

,

,

coronary artery bypass

,

cardiac surgical procedures

,

renal cell carcinoma

,

myocardial infarction

,

cardiogenic shock

,

,

inferior wall myocardial infarction

,

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

coronary disease

,

heart valve diseases

,

endometrial neoplasms

,

female genital neoplasms

,

alopecia areata

,

,

hepatocellular carcinoma

,

metabolic syndrome

,

hemolytic anemia congenital nonspherocytic

,

inborn errors pyruvate metabolism

,

hemolytic anemia

,

sickle cell anemia

,

pyruvate dehydrogenase complex deficiency disease

,

,

,

,

open-angle glaucoma

,

,

,

non-alcoholic fatty liver disease

,

,

post-acute covid-19 syndrome

,

type 2 diabetes mellitus

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

insulin resistance

,

,

erythrocyte transfusion

,

,

deficiency diseases

,

,

pancreatic neoplasms

,

,

,

hemolytic anemia congenital

,

,

,

protein deficiency

,

glycogen storage disease

,

pyruvate carboxylase deficiency disease

,

multiple acyl coenzyme a dehydrogenase deficiency

,

prediabetic state

,

,

,

pancreatic fistula

,

anastomotic leak

,

progressive supranuclear palsy

,

,

cytokine release syndrome

,

,

hyperlactatemia

,

postoperative cognitive complications

,

multiple sclerosis

,

,

guillain-barre syndrome

,

neuroinflammatory diseases

,

brain chemistry

,

,

hypertrophic cardiomyopathy

,

cardiomyopathies

,

duchenne muscular dystrophy

,

dilated cardiomyopathy

,

muscular dystrophies

,

transitional cell carcinoma

,

critical illness

,

,

korsakoff syndrome

,

alcohol amnestic disorder

,

wernicke encephalopathy

,

alcoholic korsakoff syndrome

,

muscular diseases

,

mitochondrial myopathies

,

myeloid leukemia acute

,

myeloproliferative disorders

,

myelodysplastic-myeloproliferative diseases

,

myeloid leukemia

,

clonal hematopoiesis

,

,

zika virus infection

,

,

,

patient reported outcome measures

,

,

coronary artery disease

,

myocardial ischemia

,

,

alcoholic fatty liver

,

aplastic anemia

,

,

iron metabolism disorders

,

fanconi syndrome

,

sideroblastic anemia

,

and serous mucinous cystic neoplasms

mental disorders

,

atherosclerosis

,

,

orthostatic hypotension

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

prehypertension

,

partial epilepsies

,

absence epilepsy

,

,

abdominal obesity

,

,

,

postherpetic neuralgia

,

,

,

feeding and eating disorders

,

binge-eating disorder

,

drug resistant epilepsy

,

left ventricular dysfunction

,

left ventricular hypertrophy

,

,

,

,

bipolar disorder

,

,

,

,

depressive disorder

,

type 2 diabetes mellitus

,

diabetes mellitus

,

generalized epilepsy

,

tonic-clonic epilepsy

,

essential hypertension

,

borderline personality disorder

,

personality disorders

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

aseptic meningitis

,

congenital abnormalities

,

,

facial nerve diseases

,

,

hypersensitivity

,

chronic renal insufficiency

,

kidney diseases

,

vascular diseases

healthy volunteers/patients

,

,

breast neoplasms

,

,

tobacco use disorder

,

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

keratoconjunctivitis

,

non-hodgkin lymphoma

,

,

transplantation

,

immunosuppression therapy

,

drug interactions

,

thrombocytopenia

healthy volunteers/patients

,

cardiovascular diseases

,

hemolytic anemia autoimmune

,

,

chronic kidney failure

,

bullous pemphigoid

,

hemolytic anemia

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

non-hodgkin lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

bcr-abl positive chronic myelogenous leukemia

,

myeloid leukemia

,

,

,

non-small-cell lung carcinoma

,

breast neoplasms

,

,

lymphoid leukemia

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

stomach neoplasms

,

b-cell chronic lymphocytic leukemia

,

brain neoplasms

,

neoplasm metastasis

,

squamous cell neoplasms

,

prostatic neoplasms

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

,

acute coronary syndrome

,

,

multiple myeloma

,

plasma cell neoplasms

,

squamous cell carcinoma

,

nerve degeneration

,

,

coronary artery disease

,

,

healthy volunteers/patients

,

colorectal neoplasms

,

,

,

nasopharyngeal neoplasms

,

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